Endocrine Abstracts

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...

BackgroundMedullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.Materials and methods<...

BackgroundThe management of patients with medullary thyroid cancer (MTC) has an important endocrinological aspect, because MTC can be a manifestation of multiple endocrine neoplasia syndrome (MEN), a genetically determined pathology with an autosomal dominant inheritance. MEN-2 syndrome is characterized by of MTC as a permanent feature, the combination with pheochromocytoma and/or adenoma of the parathyroid glands. The aim of the study was to determine t...